SARS-CoV2 variants differentially impact on the plasma metabolome.

ABSTRACT:

Introduction

Infection with severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) leads to COVID19 disease and caused a worldwide pandemic in 2019. Since the first wave of infections, there has been significant antigenic shifts, leading to the emergence of new variants. Today, infections have shifted away from the severe, fatal infection seen in 2019.

Objective

This study aimed to assess how the plasma metabolomes from patients varied with infection with different strains and could reflect disease severity.

Methods

Patients with COVID19 not requiring intensive care were recruited between January 2021 and May 2022 from the Queen Elizabeth Hospital Birmingham; 33 patients with alpha, 13 delta and 14 omicron variants. These were compared to 26 age matched contempo

SUBMITTER: Kramaric T 

PROVIDER: S-EPMC11972186 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature