Expression of REV7 has prognostic significance in cervical cancer treated with intensity-modulated radiation therapy.

ABSTRACT:

Background

Human cervical cancer is the fourth most common malignancies among females worldwide. Radiotherapy is crucial in the treatment of cervical cancer. REV7 is associated with the radiosensitivity of cancer cells. We aimed to investigate the relationship between the REV7 expression and the clinical outcome for patients with cervical cancer who received radiation therapy and identify new markers for studying radiosensitivity in cervical cancer.

Material and methods

The expression of REV7 in 71 cases of cervical squamous cell carcinoma (CSCC) tissues, 20 paracancerous tissues and 20 normal cervical epithelia tissues were analyzed by qRT-PCR and immunohistochemistry (IHC). Among them, 60 patients who underwent intensity-modulated radiation therapy (IMRT) and met the inclu

SUBMITTER: Chen L 

PROVIDER: S-EPMC11972243 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature