A lipid metabolism related gene signature predicts postoperative recurrence in pancreatic cancer through multicenter cohort validation.

ABSTRACT: Postoperative recurrence of pancreatic adenocarcinoma (PAAD) remains a major challenge. This study aims to establish and validate a lipid metabolism-related prognostic model to predict recurrence in PAAD patients. The TCGA-PAAD database was used to establish a training cohort, which was validated using the ICGC database and multiple center cohorts. A prognostic model based on LASSO Cox regression and a nomogram was developed and further validated. Among 196 lipid metabolism-related genes, four were selected for the prognostic model. Patients were stratified into high- and low-risk groups based on the risk score. Univariate and multivariate Cox regression analyses showed that tumor site, T stage, N stage, M stage, and risk score were significantly associated with progression-free interval (

SUBMITTER: Deng Z 

PROVIDER: S-EPMC11972318 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature