Mini-GRID therapy delivers optimised spatially fractionated radiation therapy using a flattening free filter accelerator.

ABSTRACT:

Background

Radioresistant tumours remain a challenge for conventional radiation therapy (RT), and often, only palliative treatment can be offered. Recently developed techniques, such as spatially fractionated radiation therapy (SFRT) could potentially improve treatment. However, current clinical SFRT implementations do not allow the full potential to be exploited. We further optimize SFRT, developing mini-GRID, which uses a flattening free filter accelerator.

Methods

The increase in normal tissue tolerances provided by mini-GRID compared to conventional RT and GRID therapy was validated in a rat model of brain irradiation in a longitudinal imaging study, behavioural tests and by histopathological evaluation.

Results

The implementation optimizes mini-GRID therapy, with

SUBMITTER: Acuna MI 

PROVIDER: S-EPMC11972377 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature