Targeted NMDA receptor knockdown in recall-activated neuronal ensembles impairs remote fear extinction.

ABSTRACT: Fear extinction training in rodents decreases fear responses, providing a model for the development of post-traumatic stress disorder therapeutics. Fear memory recall reactivates the consolidated fear memory trace across multiple brain regions, and several studies have suggested that these recall-activated neurons are re-engaged during extinction. However, the molecular mechanisms linking this reactivation to extinction remain largely elusive. Here, we investigated the role of N-Methyl-D-Aspartate receptors (NMDARs) in remote memory recall-activated neurons within the basolateral amygdala and the medial prefrontal cortex during extinction training in mice. We found that Grin1 knockdown in these specific ensembles impaired extinction of remote fear memory, but did not reduce their reactivat

SUBMITTER: Sung Y 

PROVIDER: S-EPMC11972453 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature