Genomic insights and epidemiology of mcr-1-Carrying Escherichia albertii isolated from agricultural soil in China.

ABSTRACT:

Background

Polymyxins are critical in treating multidrug-resistant Gram-negative bacteria infections, yet their overuse has spurred the emergence of polymyxin-resistant pathogens globally. This study aims to analyze the genomic characteristics of the Escherichia albertii strain 6S-65-1 carrying the mcr-1 gene and to investigate the global epidemiology of mcr-1-carrying E. albertii strains.

Results

In this study, we identified and analyzed a polymyxin-resistant Escherichia albertii strain (6S-65-1) carrying the mcr-1 gene, isolated from agricultural soil in China. Whole-genome sequencing and comparative genomic analyses revealed two chromosomal integrations of the mcr-1 gene within Tn6330 transposon structures, indicating its capacity for horizontal gene transfer. Strain 6S-6

SUBMITTER: Yang Y 

PROVIDER: S-EPMC11972489 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature