Infrapatellar fat pad as a source of biomarkers and therapeutic target for knee osteoarthritis.

ABSTRACT:

Background and objective

Osteoarthritis (OA) is a multifactorial and highly prevalent disease in elderly adults; however, its pathogenesis, diagnosis, and treatment are unmet needs nowadays. Research efforts have focused on elucidating the molecular mechanisms involved in the pathogenesis, onset, and progression of OA to facilitate early detection and effective therapeutic approaches. Infrapatellar fat pad (IPFP) represents a promising novel source of OA biomarkers given that it is an active player in OA. This review aims to investigate the current literature regarding the potential of the IPFP as a source of diagnostic and prognostic biomarkers for OA as well as potential target for novel therapies.

Methods

A literature search was conducted in the PubMed database in June 20

SUBMITTER: Pereira Herrera B 

PROVIDER: S-EPMC11972505 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature