Preferential transmission of minority and drug-resistant clones in polyclonal infections in Mali.

ABSTRACT:

Background

In polyclonal human malaria infections, the roles of individual clones in human-to-mosquito transmission and their relative transmissibility remain poorly understood. In addition, mutations conferring drug resistance can result in a transmission advantage or disadvantage.

Methods

Amplicon sequencing of complexity of infection and drug resistance markers was used to analyse post-treatment stage-specific malaria parasite dynamics in human blood infections and in the midguts of mosquitoes that became infected after direct membrane feeding assays (DMFAs). Blood samples originated from 50 asymptomatic Plasmodium falciparum gametocyte-carrying participants. These were collected prior to treatment and at five timepoints over 28 days following a three-day artemisinin-base

SUBMITTER: Vanheer LN 

PROVIDER: S-EPMC11972506 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature