Lung and gut microbiota profiling in intensive care unit patients: a prospective pilot study.

ABSTRACT:

Background

The gut and lung microbiomes play crucial roles in host defense and mayserve as predictive markersfor clinical outcomes in critically ill patients. Despite this, the simultaneous dynamics of lung and gut microbiomes during critical illness remain unclear. This study aims to assess the longitudinal changes in lung and gut microbiota among mechanically ventilated ICU patients with and without infection and to identify microbial features predictive of clinical outcomes, including the development of ventilator associated pneumonia (VAP).

Methods

In this prospective observational study, we analyzed 73 endotracheal aspirates (ETA) and 93 rectal swabs collected from 38 ICU patients over multiple timepoints (intubation, infection onset, post-antibiotic, and extubation/dis

SUBMITTER: Kritikos A 

PROVIDER: S-EPMC11972518 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature