The prognostic value of HFA-PEFF score in connective tissue disease-associated PAH: evidence from a cohort study.

ABSTRACT:

Background

Connective tissue disease-associated pulmonary arterial hypertension (CTD-PAH) patients with left heart dysfunction may have worse prognosis. This study was to investigate the prognostic value of HFA-PEFF score in connective tissue disease-associated PAH.

Methods

This single-center retrospective cohort study enrolled 147 CTD-PAH patients diagnosed via right heart catheterization (RHC), divided into two groups based on their HFA-PEFF scores: < 5 (n = 74) and ≥ 5 (n = 73). The clinical characteristics were compared between the two groups. The primary end point was all-cause mortality, and the secondary end point was clinical worsening events. Survival was analyzed using Kaplan-Meier analysis and Cox proportional hazards models.

Results

Compared to the HFA-PEF

SUBMITTER: Dai J 

PROVIDER: S-EPMC11972524 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature