RNA-Seq analysis reveals the long noncoding RNAs associated with immunity in wild Myotis myotis bats.

ABSTRACT:

Background

Bats possess a uniquely adapted immune system that enables them to live with viral infections without the expected maladies. The molecular basis and regulation of bats' immune response is still not fully understood. Long non-coding RNAs (lncRNAs) represent an emerging class of molecules with critical regulatory roles in multiple biological processes, including immunity. We hypothesise that lncRNA-based regulation in bats may enable them to limit disease and live with viral pathogens.

Results

We developed a lncRNA prediction pipeline to annotate the long non-coding transcriptome across multiple bat tissues and at the population level. Characterisation of our lncRNA dataset based on 100 blood transcriptomes from wild Myotis myotis bats revealed lower and more tissue

SUBMITTER: Riquier S 

PROVIDER: S-EPMC11972528 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature