A multi-center cross-sectional investigation of <i>BRAF</i> V600E mutation in Ameloblastoma.

ABSTRACT:

Background

B-Raf proto-oncogene, serine/threonine kinase (BRAF) V600E mutation stands as a pivotal genetic alteration strongly associated with several neoplasms and contributes significantly to their pathogenesis as well as potential targeted treatment strategies.

Objective

This cross-sectional study aimed to determine the frequency of BRAF V600E mutation in ameloblastoma in a multi-center of Thailand.

Method

Anti-BRAF V600E (clone VE1) immunohistochemistry was performed on 227 conventional ameloblastoma (AM) and 113 unicystic ameloblastoma (UA) samples collected from four major dental schools located in the Central, North, South, and Northeast regions of Thailand. Tumor cells from randomly chosen AM cases were also micro-dissected from the FFPE sections

SUBMITTER: Tun KM 

PROVIDER: S-EPMC11972564 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature