Prediction of breast cancer risk for adolescents and young adults with Hodgkin lymphoma.

ABSTRACT:

Background

Although female survivors of Hodgkin lymphoma (HL) have an increased risk of breast cancer (BC), no BC risk prediction model is available. We developed such models incorporating mean radiation dose to the breast or breast quadrant-specific radiation doses.

Methods

Relative risks and age-specific incidence for BC and competing events (mortality or other subsequent cancer) were estimated from 1194 Dutch 5-year HL survivors, treated at ages 11-40 during 1965-2000. Predictors were doses to 10 breast segments or mean breast radiation dose, BC family history, year of and age at HL diagnosis, and ages at menopause and first live birth. Models were independently validated using US Childhood Cancer Survivor Study cohort participants.

Results

Predicted absolute BC ri

SUBMITTER: Roberti S 

PROVIDER: S-EPMC11972682 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature