Cutoff value of serum 25-hydroxyvitamin D leading to vitamin D deficiency for children in Japan.

ABSTRACT: The 25-hydroxyvitamin D [25(OH)D] level and clinical symptoms are used to diagnose vitamin D deficiency (VDD). The current 25(OH)D cutoff value is based on biochemical findings, such as elevated parathyroid hormone (PTH) levels, rather than clinical symptoms. However, low 25(OH)D levels do not necessarily produce clinical symptoms. The present study proposed a 25(OH)D cutoff value for diagnosing manifest VDD, defined as VDD that is diagnosable based on either clinical symptoms, such as rickets and/or hypocalcemia (symptomatic VDD), or biochemical findings, such as elevated PTH and alkaline phosphatase levels (biochemical VDD). One hundred and eighty participants aged 0-15 yr with suspected VDD were enrolled, and receiver operating characteristic curve analysis was performed. Sixty-seven an

SUBMITTER: Ogiwara Y 

PROVIDER: S-EPMC11972867 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature