A novel thrombospondin-1 variant as a potential diagnostic biomarker and therapeutic target in canine mammary tumor and osteosarcoma cells.

ABSTRACT:

Importance

Thrombospondin-1 (TSP1) is a vital glycoprotein that plays a key role in critical biological functions, including cell migration, invasion, angiogenesis, and proliferation. Understanding the roles of its variants, particularly TSP1 variant (TSP1V), is critical for cancer biology and therapy.

Objective

This study examined the expression of the transcriptional variant TSP1V, focusing on canine TSP1 sequences.

Methods

The expression of canine TSP1 sequences was analyzed using a reverse transcription polymerase chain reaction (RT-PCR) to identify the TSP1 wild-type (dTSP1W) and novel canine TSP1V transcripts (dTSP1V). The effects of damnacanthal and genistein, anticancer compounds, on the viability of canine mammary and osteosarcoma

SUBMITTER: Hong Y 

PROVIDER: S-EPMC11972944 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature