Epigenomics and transcriptomics association study of blood pressure and incident diagnosis of hypertension in twins.

ABSTRACT: Hypertension is the most frequent health-related condition worldwide and is a primary risk factor for renal and cardiovascular diseases. However, the underlying molecular mechanisms are still poorly understood. To uncover these mechanisms, multi-omics studies have significant potential, but such studies are challenged by genetic and environmental confounding - an issue that can be effectively reduced by studying intra-pair differences in twins. Here, we coupled data on hypertension diagnoses from the nationwide Danish Patient Registry to a study population of 740 twins for whom genome-wide DNA methylation and gene expression data were available together with measurements of systolic and diastolic blood pressure. We investigated five phenotypes: incident hypertension cases, systolic blood p

SUBMITTER: Skovgaard AC 

PROVIDER: S-EPMC11972964 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature