Structural changes in cerebral microvasculature induced by ferroptosis contribute to blood-brain barrier disruption in Alzheimer's disease: an autopsy study.

ABSTRACT:

Introduction

Cerebrovascular lesions are associated with cognitive impairment. However, the impact of AD neuropathological changes (ADNC) on cerebral microvasculature is not completely understood.

Methods

Twelve decedents with ADNC and 15 matched controls were selected from the Brain Bank. The changes in the median tunica and basement membrane-related extracellular matrix (ECM) contents of the microvasculature were quantified and compared. Additionally, we explored the related mechanisms of agrin in pericytes.

Results

Venular collagenosis was significantly more severe in AD patients (p < 0.001), and ECM remolding was significantly correlated with ADNC. In the AD group, blood-brain barrier (BBB) disruption and decreased pericytes were observed. Finally, we confirmed th

SUBMITTER: Cao Y 

PROVIDER: S-EPMC11972978 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature