Brain cholinergic terminal density utilizing [¹⁸F]-fluoroethoxybenzovesamicol PET in adults with Down's syndrome: Relationship to amyloid PET and cognitive performance.

ABSTRACT:

Background

Adults with Down syndrome (DS) have increased risk of Alzheimer's disease (AD). The cholinergic system declines in AD, underlying many cognitive deficits. We investigated the relationship between amyloid accumulation and cholinergic terminal density in adults with DS compared to amyloid-matched controls.

Methods

A total of 15 non-demented adults with DS and 15 amyloid-matched healthy controls were assessed for [¹⁸F]-FEOBV uptake differences and [¹⁸F]-FEOBV uptake relationships with amyloid accumulation and cognitive performance.

Results

Adults with DS displayed greater [¹⁸F]-FEOBV uptake than controls, with a similar uptake pattern. Amyloid-associated differences in [¹⁸F]-FEOBV uptake were observed in adults with

SUBMITTER: Russell JK 

PROVIDER: S-EPMC11972980 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature