Platelets mirror changes in the frontal lobe antioxidant system in Alzheimer's disease.

ABSTRACT:

Introduction

Blood biomarkers reflecting Alzheimer's disease (AD) pathophysiology can improve diagnosis and treatment.

Methods

We applied top-down proteomics to compare frontal lobe from 17 AD cases and 11 controls to blood platelets from a second independent study group of 124 AD patients, 61 with mild cognitive impairment (MCI), and 168 controls. Findings were immunologically validated.

Results

Sixty AD-associated proteoforms were identified in frontal lobe, with 26 identically represented in platelets. Validation in platelet samples confirmed elevated glutathione S-transferase omega 1 (GSTO1) levels linked to single nucleotide polymorphism (SNP) rs4925 and increased superoxide dismutase 1 (SOD1) levels in AD. Bioinformatics revealed copper chaperone for superoxide

SUBMITTER: Ercan H 

PROVIDER: S-EPMC11972982 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature