The striatum is an early, accurate indicator of amyloid burden using [¹¹C]PiB in Down syndrome: Comparison of two radiotracers.

ABSTRACT:

Introduction

Adults with Down syndrome demonstrate striatum-first amyloid accumulation with [¹¹C]Pittsburgh Compound-B (PiB) positron emission tomography (PET) imaging, which has not been replicated with [¹⁸F]florbetapir (FBP). Early striatal accumulation has not been temporally quantified with respect to global cortical measures.

Methods

Longitudinal PiB (n = 175 participants) and FBP (n = 92 participants) data from the Alzheimer Biomarkers Consortium-Down Syndrome (ABC-DS) were used to measure cortical and striatal binding. Generalized temporal models for cortical and striatal amyloid accumulation were created using the sampled iterative local approximation (SILA) method.

Results

PiB demonstrated greater striatal-to-cortical ratios than FBP. SI

SUBMITTER: McLachlan M 

PROVIDER: S-EPMC11972983 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature