White matter hyperintensity spatial patterns: Risk factors and clinical correlates.

ABSTRACT:

Introduction

White matter hyperintensities (WMHs), a major cerebral small vessel disease (cSVD) marker, may arise from different pathologies depending on their location. We explored clinical and genetic correlates of agnostically derived spatial WMH patterns in two longitudinal population-based cohorts (Three-City Study [3C]-Dijon, LIFE-Adult).

Methods

We derived seven WMH spatial patterns using Bullseye segmentation in 2878 individuals aged 65+ and explored their associations with vascular and genetic risk factors, cognitive performance, dementia and stroke incidence.

Results

WMHs in the frontoparietal and anterior periventricular region were associated with blood pressure traits, WMH genetic risk score (GRS), baseline and decline in general cognitive performance, in

SUBMITTER: Beyer F 

PROVIDER: S-EPMC11972985 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature