Exploring the impact of orthodontic appliances on the oral microbiome and inflammatory parameters.

ABSTRACT:

Background

The symbiotic relationship between the oral microbiome and the host immune system is a prerequisite of oral health. Disruptions to this system can be associated with the development of diseases like dental caries. Introducing orthodontic treatments, such as aligners and fixed appliances, might impact this microbial ecosystem. This study evaluated potential changes in salivary microbiome and the level of inflammatory marker myeloid-related protein 8/14 in patients undergoing orthodontic treatment with aligners or fixed appliances.

Methods

Forty-eight patients were divided into two groups for treatment with fixed appliances or clear aligners. Unstimulated saliva samples were collected at baseline, three, and six months for microbiome analysis via 16 S rRNA sequencin

SUBMITTER: Nemec M 

PROVIDER: S-EPMC11973030 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature