The role of UPK1B in gastric cancer: multi-omics analysis and experimental validation.

ABSTRACT:

Background

UPK1B has been implicated in various cancers; however, its mechanism of action in gastric cancer remains elusive.

Methods

We utilized transcriptional data and clinical information, and mutation profiles from The Cancer Genome Atlas (TCGA) database to analyze UPK1B's expression and clinical relevance. Biological enrichment, immune microenvironment characterization, and drug sensitivity analyses were conducted. Functional assays, including proliferation, migration, invasion, and in vivo metastasis models, were used to validate UPK1B's role in gastric cancer.

Results

UPK1B was significantly upregulated in gastric cancer and correlated with worse clinical outcomes, including advanced stages and reduced survival rates. Biological enrichment analysis revealed its

SUBMITTER: Zhu H 

PROVIDER: S-EPMC11973043 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature