Gut Microbiota and Their Metabolites: The Hidden Driver of Diabetic Nephropathy? Unveiling Gut Microbe's Role in DN.

ABSTRACT:

Background

Diabetic nephropathy (DN) is a severe microvascular complication of diabetes with a complex pathogenesis.

Methods

Recent studies were reviewed to explore the role of gut microbiota and its metabolites in DN development.

Results

Dysbiosis of gut bacteria contributes to pathological changes such as glomerular sclerosis and renal tubule injury. Microbial metabolites are involved in DN through immune and inflammatory pathways.

Conclusions

Understanding the relationship between gut microbiota, its metabolites, and DN may offer potential implications for DN diagnosis, prevention, and treatment. Translating this knowledge into clinical practice presents challenges and opportunities.

SUBMITTER: Liu J 

PROVIDER: S-EPMC11973130 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature