Elucidating molecular lipid perturbations in trigeminal neuralgia using cerebrospinal fluid lipidomics.

ABSTRACT: Trigeminal neuralgia (TN) is a neuropathic facial pain disorder characterized by severe stabbing pain along the trigeminal nerve. While its pathogenesis remains unclear, nerve demyelination and inflammation are likely involved. Current research has primarily focused on various blood-based omics approaches, which do not fully capture the lipid alterations occurring during TN progression in brain. In contrast, our study is the first to investigate cerebrospinal fluid (CSF) lipidomic profiles in TN patients, aiming to elucidate potential disease mechanisms. CSF samples were collected from 22 TN patients and 18 healthy controls, followed by untargeted lipidomic analysis using high-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry. A pipeline for lipid ide

SUBMITTER: Xu D 

PROVIDER: S-EPMC11973149 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature