Three-dimensional organ segmentation-derived CT attenuation parameters for assessing hepatic steatosis in chronic hepatitis B patients.

ABSTRACT: The utility of CT-derived parameters for hepatic steatosis assessment has primarily focused on non-alcoholic fatty liver disease. This study aimed to evaluate their applicability in chronic hepatitis B (CHB) through a retrospective analysis of 243 CHB patients. Using deep-learning-based 3D organ segmentation on abdominal CT scans at 100 kVp, the mean volumetric CT attenuation of the liver and spleen was automatically measured on pre-contrast (liver (L)_pre and spleen (S)_pre) and post-contrast (L_post and S_post) portal venous phase images. To identify mild, moderate, and severe steatosis (S1, S2, and S3 based on the controlled attenuation parameter), L_pre showed areas under the receiver operating characteristic curve (AUROCs) of 0.695, 0.779, and 0.795, significantly higher than L-S_pre

SUBMITTER: Yoo J 

PROVIDER: S-EPMC11973153 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature