Htra4 promotes vascular endothelial cell injury and is associated with the early-onset of preeclampsia.

ABSTRACT: Preeclampsia (PE) is a pregnancy-specific disorder characterized by multi-system involvement, leading to increased perinatal morbidity and mortality as well as long-term cardiovascular damage in both mother and fetus. This study aimed to investigate the alterations and potential role of high temperature requirement factor A4 (Htra4) in early-onset PE. We conducted a comparative analysis of the baseline data between patients with early-onset PE and normal controls, as well as analyzed the correlation of Htra4 levels in the peripheral blood with pregnancy outcomes. Additionally, we investigated the impact of recombinant protein Htra4 on human umbilical vein endothelial cells (HUVECs). Patients with early-onset PE patients exhibited cardiac, hepatic, and renal impairment, as well as elevated

SUBMITTER: Kong H 

PROVIDER: S-EPMC11973184 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature