Associations between <i>APOE-TOMM40 '523</i> haplotypes and limbic system white matter microstructure.

ABSTRACT:

Introduction

We assessed associations between apolipoprotein E Translocase of Outer Mitochondrial Membrane 40 (APOE-TOMM40)-'523 haplotypes and white matter microstructure (WMM) across limbic tracts important for memory and cognition in non-Hispanic Black and White individuals.

Methods

Linear regression models, stratified by APOE and racialized groups, assessed associations between TOMM40-'523-S and limbic tract WMM free-water (FW) and free-water-corrected fractional anisotropy (FAFWcorr).

Results

Black-ε4+-one-'523-S carriers had lower FW in the cingulum and inferior longitudinal fasciculus compared to Black-ε4+-no-'523-S carriers. Additionally, Black-ε4+-one-'523-S carriers had lower FW in the cingulum, uncinate, and fornix, and higher FA_FW

SUBMITTER: Mooney KE 

PROVIDER: S-EPMC11973251 | biostudies-literature | 2025 Apr-Jun

REPOSITORIES: biostudies-literature