Loss of age-accumulated <i>crh-1</i> circRNAs ameliorate amyloid β-induced toxicity in a <i>C. elegans</i> model for Alzheimer's disease.

ABSTRACT: Circular RNAs (circRNAs) are non-coding RNAs mostly derived from exons of protein-coding genes via a back-splicing process. The expression of hundreds of circRNAs accumulates during healthy aging and is associated with Alzheimer's disease (AD), which is characterized by the accumulation of amyloid-beta (Aβ) proteins. In C. elegans, many circRNAs were previously found to accumulate during aging, with loss of age-accumulated circRNAs derived from the CREB gene (circ-crh-1) to increase mean lifespan. Here, we used C. elegans to study the effects of age-accumulated circRNAs on the age-related onset of Aβ-toxicity. We found that circ-crh-1 mutations delayed Aβ-induced muscle paralysis and lifespan phenotypes in a transgenic C. elegans strain expressing a full-

SUBMITTER: Alshareef HZ 

PROVIDER: S-EPMC11973312 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature