Investigating low intensity focused ultrasound pulsation in anhedonic depression-A randomized controlled trial.

ABSTRACT:

Introduction

Anhedonic depression is a subtype of depression characterized by deficits in reward processing. This subtype of depression is associated with higher suicide risk and longer depressive episodes, underscoring the importance of effective treatments. Anhedonia has also been found to correlate with alterations in activity in several subcortical regions, including the caudate head and nucleus accumbens. Low intensity focused ultrasound pulsation (LIFUP) is an emerging technology that enables non-invasive stimulation of these subcortical regions, which were previously only accessible with surgically-implanted electrodes.

Methods

This double-blinded, sham-controlled study aims to investigate the effects of LIFUP to the left caudate head and right nucleus accumbens in pa

SUBMITTER: Rotstein NM 

PROVIDER: S-EPMC11973349 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature