Discovery of KDM5D as a novel biomarker for traumatic brain injury identified through bioinformatics analysis.

ABSTRACT:

Background and aim

Traumatic brain injury (TBI) poses a significant burden on the global economy due to its poor treatment and prognosis. Current TBI markers do not comprehensively reflect the disease status. Therefore, identifying more meaningful biomarkers is beneficial for improving the prognosis and clinical treatment of TBI patients.

Methods

The gene expression profile of TBI was obtained from the Gene Expression Omnibus (GEO) database. Differentially expressed genes (DEGs) were subjected to enrichment analysis, and key potential genes were identified through the protein-protein interaction network and cytoHubba modules. ROC curves were used to construct diagnostic models for hub genes. Immunofluorescence experiments were conducted to detect the expression of candidate

SUBMITTER: Ding D 

PROVIDER: S-EPMC11973351 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature