Efficacy and cost-effectiveness analysis of 10-day versus 14-day eradication of <i>Helicobacter pylori</i> infection with vonoprazan amoxicillin: a prospective, multicenter, randomized controlled trial.

ABSTRACT:

Objectives

To evaluate the efficacy and cost-effectiveness of 10-day vonoprazan-amoxicillin (VA) dual therapy compared to 14-day VA therapy.

Methods

A non-inferiority trial was carried out at 10 clinical centers to recruit patients with H. pylori infection. Subjects were assigned at random to either the group for 10-day or 14-day, and where given vonoprazan 20 mg bid and amoxicillin 1 g tid. Comparisons were made in terms of eradication rates, adverse events, cost-effectiveness, and compliance.

Results

914 participants were enrolled and randomly assigned to either the 10-day or 14-day VA groups. Using the intention-to-treat principle and multiple imputation for missing outcomes, the analysis showed an eradication rate of 88.79% in the 10-day group and 92.37% in the 14

SUBMITTER: Dong Y 

PROVIDER: S-EPMC11973372 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature