The gene regulatory basis of bystander activation in CD8⁺ T cells.

ABSTRACT: CD8⁺ T cells are classically recognized as adaptive lymphocytes based on their ability to recognize specific foreign antigens and mount memory responses. However, recent studies indicate that some antigen-inexperienced CD8⁺ T cells can respond to innate cytokines alone in the absence of cognate T cell receptor stimulation, a phenomenon referred to as bystander activation. Here, we demonstrate that neonatal CD8⁺ T cells undergo a robust and diverse program of bystander activation, which corresponds to enhanced innate-like protection against unrelated pathogens. Using a multi-omics approach, we found that the ability of neonatal CD8⁺ T cells to respond to innate cytokines derives from their capacity to undergo rapid chromatin remodeling, resulting

SUBMITTER: Watson NB 

PROVIDER: S-EPMC11973513 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature