Effect of benralizumab treatment on the airway microbiome in COPD.

ABSTRACT:

Background

One-third of patients with COPD have an eosinophilic inflammatory phenotype. Benralizumab is an afucosylated humanised monoclonal antibody that targets the interleukin-5 receptor α subunit, leading to rapid and near-complete eosinophil depletion via antibody-dependent cellular cytotoxicity. We hypothesised that benralizumab-targeted immune modulation could have an impact on the airway microbiome in COPD. The objective of the present study was to investigate the effect of benralizumab treatment on inflammation and the sputum microbiome in COPD.

Methods

Sputum samples from 94 COPD patients enrolled to the GALATHEA trial (NCT02138916) and randomised to receive placebo (33), benralizumab at 100 mg (29) or 30 mg (32) over 52 weeks were analysed at baseline, week

SUBMITTER: Haldar K 

PROVIDER: S-EPMC11973710 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature