Clinical prognostic models for sarcomas: a systematic review and critical appraisal of development and validation studies.

ABSTRACT:

Background

Current clinical guidelines recommend the use of clinical prognostic models (CPMs) for therapeutic decision-making in sarcoma patients. However, the number and quality of developed and externally validated CPMs is unknown. Therefore, we aimed to describe and critically assess CPMs for sarcomas.

Methods

We performed a systematic review including all studies describing the development and/or external validation of a CPM for sarcomas. We searched the databases MEDLINE, EMBASE, Cochrane Central, and Scopus from inception until June 7th, 2022. The risk of bias was assessed using the prediction model risk of bias assessment tool (PROBAST).

Results

Seven thousand six hundred fifty-six records were screened, of which 145 studies were eventually included, developing

SUBMITTER: Heesen P 

PROVIDER: S-EPMC11974052 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature