Induction of apoptosis and hypoxic stress in malignant melanoma cells via graphene-mediated far-infrared radiation.

ABSTRACT:

Background

Malignant melanoma (MM) is a highly aggressive skin tumor with a rising incidence and poor prognosis. Although current clinical treatments, including surgery, targeted therapy, immunotherapy, and radiotherapy, have shown some efficacy, therapeutic options remain limited for elderly patients and those with metastatic disease, highlighting the urgent need for novel therapeutic strategies. In recent years, the unique far-infrared radiation (FIR) properties of graphene have demonstrated potential applications in cancer treatment. However, the mechanisms underlying FIR's effects in MM therapy remain poorly understood.

Methods

This study systematically evaluated the inhibitory effects of FIR on MM through in vitro cell experiments, animal models, and molecular mechanism

SUBMITTER: Zhao W 

PROVIDER: S-EPMC11974076 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature