GINS1 facilitates the development of lung adenocarcinoma via Wnt/β-catenin activation.

ABSTRACT:

Background

Lung adenocarcinoma(LUAD) is the primary reason for cancer-related deaths globally. GINS1 has a significant regulatory function in DNA replication. It is overexpressed in various malignant tumors, but the specific molecular mechanisms of GINS1 in LUAD pathogenesis are not fully elucidated. This is the first report that GINS1 enhances LUAD by activating Wnt/β-catenin signaling pathway, and may serve as a potential target for therapy.

Methods

Bioinformatic analysis including analysis of difference, survival analysis and pathway enrichment, immunohistochemistry(IHC), western blotting(WB), and quantitative real time polymerase chain reaction(qRT-PCR) were used to detect GINS1 expression in LUAD cell lines and tissues. A range of in vivo and in vitro experiments, such

SUBMITTER: Ma L 

PROVIDER: S-EPMC11974172 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature