Limbic system abnormalities in episodic cluster headache: a 7T MRI multimodal study.

ABSTRACT:

Background

Although the limbic system has long been thought to be involved in the pathophysiology of cluster headache, inconsistencies in imaging studies of episodic cluster headache (eCH) patients and limited understanding of the specific regions within the limbic system have prevented a full explanation of its involvement in the disease. Therefore, we performed multimodal imaging analysis using 7 T MRI with the aim of exploring structural-functional abnormalities in subregions of the limbic system and their relationship with clinical features.

Methods

In this cross-sectional study, we employed 7T MRI to investigate structural (volumetric) and functional (fractional amplitude of low-frequency fluctuations (fALFF), regional homogeneity (ReHo)) alterations in limbic subregion

SUBMITTER: Wang X 

PROVIDER: S-EPMC11974220 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature