MeCP2 Modulates Depression-Like Behaviors Comorbid to Chronic Pain by Regulating Adult Hippocampal Neurogenesis.

ABSTRACT:

Aims

Although previous studies have revealed the association between chronic pain-induced depression and defective adult hippocampal neurogenesis (AHN), the underlying molecular mechanism remains elusive. This study aims to examine the association between AHN and depression-like behaviors, and to reveal the underlying mechanisms.

Methods

The chronic neuropathic pain model was established using mice with the spared nerve injury (SNI) surgery. The depression-like behaviors were evaluated by using the sucrose preference test (SPT), the tail suspension test (TST), the forced swimming test (FST), and the open field test (OFT). The expression of Methyl-CpG-binding protein 2 (MeCP2) was modulated by injecting the adeno-associated virus (AAV) with the DIO system into the ventral DG

SUBMITTER: Sun Y 

PROVIDER: S-EPMC11974449 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature