Gelatin methacryloyl biomaterials and strategies for trophoblast research.

ABSTRACT: Rising maternal mortality rates in the U.S. are a significant public health issue that must be addressed; however, much of the basic science information required to target pregnancy-related pathologies have not yet been defined. Placental and blastocyst implantation research are challenging to perform in humans because of the early time frame of these processes in pregnancy and limited access to first trimester tissues. As a result, there is a critical need to develop model systems capable of studying these processes in increasing mechanistic detail. With the recent passing of the FDA Modernization Act 2.0 and advances in tissue engineering methods, three-dimensional microphysiological model systems offer an exciting opportunity to model early stages of placentation. Here, we detail the sy

SUBMITTER: Zambuto SG 

PROVIDER: S-EPMC11974609 | biostudies-literature | 2024 Nov

REPOSITORIES: biostudies-literature