Yes-associated Protein Induces Age-dependent Inflammatory Signaling in the Pulmonary Endothelium.

ABSTRACT: Acute Lung Injury (ALI) causes the highly lethal Acute Respiratory Distress Syndrome (ARDS) in children and adults, for which therapy is lacking. Children with Pediatric ARDS (PARDS) have a mortality rate that is about half of adults with ARDS. Improved ALI measures can be reproduced in rodent models with juvenile animals, suggesting that physiologic differences may underlie these outcomes. Here, we show that pneumonia-induced ALI caused inflammatory signaling in the endothelium of adult mice which depended on Yes-associated protein (YAP). This signaling was not present in 21-day-old weanling mice. Transcriptomic analysis of lung endothelial responses revealed nuclear factor kappa-B (NF-κB) as significantly increased with ALI in adult versus weanling mice. Blockade of YAP signaling protect

SUBMITTER: Emin MT 

PROVIDER: S-EPMC11974671 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature