Decreased hippocampal neurite density in late middle-aged adults following prenatal exposure to higher levels of maternal inflammation.

ABSTRACT: In animal models, exposure to heightened maternal inflammation in utero is associated with altered offspring hippocampal development, including reduced dendritic arborization and density. However, the effects of prenatal maternal inflammation (PNMI) on offspring hippocampal microstructure in humans remains unclear. Here, we examined the relationship between exposure to PNMI and neurite density in the hippocampus and its subfields among offspring during late middle age. Participants included 72 mother-offspring dyads from the Child Health and Development Studies (CHDS) cohort. Data for four inflammatory biomarkers (IL-6, IL-8, IL-1 receptor antagonist [IL-1RA], and soluble TNF receptor-II [sTNF-RII]) were available from first and second trimester maternal sera. Neurite density in the offspr

SUBMITTER: Mohyee RA 

PROVIDER: S-EPMC11974695 | biostudies-literature | 2025 Aug

REPOSITORIES: biostudies-literature