The origin, invasion history and resistance architecture of <i>Anopheles stephensi</i> in Africa.

ABSTRACT: The invasion of Africa by the Asian urban malaria vector, Anopheles stephensi, endangers 126 million people across a rapidly urbanising continent where malaria is primarily a rural disease. Control of An. stephensi requires greater understanding of its origin, invasion dynamics, and mechanisms of widespread resistance to vector control insecticides. We present a genomic surveillance study of 551 An. stephensi sampled across the invasive and native ranges in Africa and Asia. Our findings support a hypothesis that an initial invasion from Asia to Djibouti seeded separate incursions to Sudan, Ethiopia, and Yemen before spreading inland, aided by favourable temperature, vegetation cover, and human transit conditions. Insecticide resistance in invasive An. stephensi

SUBMITTER: Dennis TPW 

PROVIDER: S-EPMC11974716 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature