High-Definition MEG Source Estimation using the Reciprocal Boundary Element Fast Multipole Method.

ABSTRACT: Magnetoencephalographic (MEG) source estimation relies on the computation of the gain (lead-field) matrix, which embodies the linear relationship between the amplitudes of the sources and the recorded signals. However, with a realistic forward model, the calculation of the gain matrix in a "direct" fashion is a computationally expensive task because the number of dipolar sources in standard MEG pipelines is often limited to ~10,000. We propose a fast approach based on the reciprocal relationship between MEG and transcranial magnetic stimulation (TMS). This approach couples naturally with the charge-based boundary element fast multipole method (BEM-FMM), which allows us to efficiently generate gain matrices for high-resolution multi-layer non-nested meshes involving source spaces of

SUBMITTER: Ponasso GN 

PROVIDER: S-EPMC11974733 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature