Mapping the Psychosis Spectrum - Imaging Neurosubtypes from Multi-Scale Functional Network Connectivity.

ABSTRACT: This study aims to identify Psychosis Imaging Neurosubtypes (PINs)- homogeneous subgroups of individuals with psychosis characterized by distinct neurobiology derived from imaging features. Specifically, we utilized resting-state fMRI data from 2103 B-SNIP 1&2 participants (1127 with psychosis, 350 relatives, 626 controls) to compute subject-specific multiscale functional network connectivity (msFNC). We then derived a low-dimensional neurobiological subspace, termed Latent Network Connectivity (LNC), which captured system-wide interconnected multiscale information across three components (cognitive-related, typical, psychosis-related). Projections of psychosis participants' msFNC onto this subspace revealed three PINs through unsupervised learning, each with distinct cognitive, clinical,

SUBMITTER: Ballem R 

PROVIDER: S-EPMC11974735 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature