Dim Light at Night Disrupts the Sleep-Wake Cycle and Exacerbates Seizure Activity in <i>Cntnap2</i> Knockout Mice: Implications for Autism Spectrum Disorders.

ABSTRACT: Epilepsy is one of the most common comorbidities in individuals with autism spectrum disorders (ASDs). Many patients with epilepsy as well as ASD experience disruptions in their sleep-wake cycle and exhibit daily rhythms in expression of symptoms. Chronic exposure to light at nighttime can disrupt sleep and circadian rhythms. Contactin associated protein-like 2 knockout (Cntnap2 KO) mice, a model for autism spectrum disorder (ASD) and epilepsy, exhibit sleep and circadian disturbances and seizure-like events. This study examines how chronic dim light at night (DLaN) exposure affects sleep architecture, EEG power spectra, and seizure activity in Cntnap2 KO and wildtype (WT) mice. Using electroencephalography (EEG) recordings, male and female Cntnap2 KO and WT mice were

SUBMITTER: Wang Y 

PROVIDER: S-EPMC11974761 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature