Combined MEG and EEG suggest a limbic source network of the P3 including retrosplenial cortex and hippocampus.

ABSTRACT: The event-related P3 is evoked by most task-relevant or salient stimuli, but its neural generators have remained controversial, limiting the integration of P3 with functional neuroimaging. Here we reevaluate the role of hippocampus and retro-splenial cortex as potential generators of the P3. Combined magneto- and electroencephalography signals were recorded during a visual oddball paradigm. Observers were instructed to respond to rare targets of a deviant shape and ignore rare non-targets of a deviant color. Source analysis was based on noise-normalized minimum-norm estimates in an individual, MRI-based source space. Critically, the cortical source space was extended to include the cornu ammonis of the hippocampus. Source analysis at the P3 peak showed strong sources in retrosplenial corte

SUBMITTER: Das D 

PROVIDER: S-EPMC11974766 | biostudies-literature | 2025 Jun

REPOSITORIES: biostudies-literature