Umbilical cord blood pTau217 and BD-tau are associated with markers of neonatal hypoxia: a prospective cohort study.

ABSTRACT:

Objective

Current methods for early detection of hypoxic-ischemic encephalopathy (HIE) are limited by lack of specificity, cost, and time constraints. Blood tau protein concentrations reflect neuropathology in adults. This study examines tau as a potential HIE biomarker in neonates by relating cord blood levels to short-term fetomaternal outcomes. We aimed to examine 1) association of BD-tau with non-reassuring fetal status; 2) correlations between cord blood tau and other hypoxia biomarkers; 3) associations between tau levels and risk factors for fetomaternal morbidity; 4) associations between tau levels and short-term fetomaternal outcome.

Methods

107 maternal participants were prospectively recruited at Royal Prince Alfred Hospital-a large Australian tertiary referral cen

SUBMITTER: Payne E 

PROVIDER: S-EPMC11974770 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature