Short-term alterations in dietary amino acids override host genetic susceptibility and reveal mechanisms of <i>Salmonella</i> Typhimurium small intestine colonization.

ABSTRACT: In addition to individual genetics, environmental factors (e.g., dietary changes) may influence host susceptibility to gastrointestinal infection through unknown mechanisms. Herein, we developed a model in which CBA/J mice, a genetically resistant strain that tolerates intestinal colonization by the enteric pathogen Salmonella Typhimurium (S. Tm), rapidly succumb to infection after exposure to a diet rich in L-amino acids (AA). In mice, S. Tm-gastroenteritis is restricted to the large intestine (cecum), limiting their use to understand S. Tm small intestine (ileum) colonization, a feature of human Salmonellosis. Surprisingly, CBA mice fed AA diet developed ileitis with enhanced S. Tm ileal colonization. Using germ-free mice and ileal-fecal slurry transpla

SUBMITTER: Shealy NG 

PROVIDER: S-EPMC11974825 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature