Helminth infection favors reprogramming and proliferation of lung neutrophils.

ABSTRACT: Neutrophils are a granulocytic population of myeloid cells that have critical effector functions during infectious disease but are generally thought to be short-lived and nonproliferative with markedly limited activation states. In these studies, we directly compared lung neutrophil activation following infection with different groups of pathogens including bacteria, fungi, and helminths. Our results demonstrate considerable heterogeneity depending on the type of infectious agent. In contrast to bacterial and fungal infection, after helminth infection neutrophils expressed markers associated with characteristic type 2 responses and unexpectedly upregulated genes associated with cell cycling and protein synthesis. Further studies showed reduced neutrophil cell death following helminth infec

SUBMITTER: Chen F 

PROVIDER: S-EPMC11974826 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature